A case of CD56+ cutaneous aleukaemic granulocytic sarcoma with myelodysplastic syndrome. granulocytic sarcoma. Granulocytic (myeloid) sarcoma (GS) is a rare hematological neoplasm composed of immature myeloid cells at an extramedullary site which may precede leukemia; nevertheless, the most frequent clinical presentation is secondary to acute or chronic myeloid leukemia, or myelodysplastic syndrome [1, 2] developing within an average of 6–12 months after primary diagnosis []. Intracardiac echocardiography-guided biopsy of the tumour revealed the tissue diagnosis-granulocytic sarcoma of the heart. Myeloid sarcoma (also known as granulocytic sarcoma, chloroma, and extramedullary myeloid tumor) is defined as an extramedullary mass-forming lesion of immature myeloid cells (Fig. This presentation details the authors’ experience with 61 biopsy-proven granulocytic sarcomas. Pan T cell marker Diagnosis of myeloid (granulocytic) sarcoma (J Clin Pathol 2005;58:211) Classify subtypes of T cell lymphomas and low grade B cell lymphomas Differentiate pulmonary MALT lymphoma (CD20+ CD43+) from lymphoid hyperplasia (CD43 negative, Am J Surg Pathol 2002;26:76) Granulocytic sarcoma of the gastrointestinal tract most frequently involves the small intestine and most often presents with abdominal pain and obstruction. 14.20) and is diagnostic of AML, even without 20% blood or marrow blasts. On rare occasions, the lesion precedes the leukemic phase and presents as a mass with a normal peripheral white cell count. Histological diagnosis can be difficult in patients with poorly differentiated orbital tumours and no evidence of systemic leukaemia. Spahr J, Behm FG, Schneider V. Granulocytic sarcoma is an unusual form of tumefaction caused by acute granulocytic leukemia. Preleukemic granulocytic sarcoma of cervix and vagina: initial manifestation by cytology. A 56-year-old man had a history of acute promyelocytic leukemia and had been in remission for 2 years. AIM Orbital granulocytic sarcoma is a localised tumour composed of cells of myeloid origin. As predicted by the unusual clinical manifestations and radiological findings, the patient's survival was short. Spinal fluid cytology was negative for malignant cells. Eleven patients, 13 to 76 (mean, 40) years of age, had granulocytic sarcoma of the female genital tract (FGT) (ovary, seven cases; vagina, three cases; cervix, one case).In nine cases, the FGT involvement was the initial clinical presentation of the disease, and in the other two cases, the FGT involvement was discovered during a relapse of acute myeloid leukemia. Cardiac magnetic resonance imaging and computed tomography demonstrated extracardiac tumour invasion of the free atrial wall extending to the right pulmonary hilus. Brain MRI showed 2 well-circumscribed right parietal lobe lesions (one lesion shown above). 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